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Epitomax (Topiramate)
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Topiramate

Epitomax is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, Epitomax was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults. Characteristics that distinguish Epitomax from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.4 Interestingly, Epitomax was discovered by chance when attempts were made to formulate a novel antidiabetic drug.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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In contrast, hypomorphic Artemis mutations result in combined immunodeficiency syndromes of varying severity, but, in addition, are hypothesized to predispose to lymphoid malignancy. Hepatitis C virus (HCV) infection is one of the major causes of chronic liver diseases. Intensive doses of chemotherapy are used to counter mechanisms of drug resistance.

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We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN. Delayed parenthood on the rise: A call for upstream preconception health promotion in Canada. Progressive and rapid symptom deterioration leads to an impairment of functional status and compromised healthrelated quality-of-life (HrQoL) simultaneously.

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Antidepressants proved effective in reducing disease activity, gastrointestinal symptoms, anxiety and depression. The approach thereby provides a principled alternative to a common tradition of defending and minimizing deviations from nature in artificial life. Despite the availability of treatment that is expected to cure most cases of TB, levels of MDR-TB remain worryingly high in India. Extracellular vesicles as potential biomarkers of acute graft-vs-host disease. New-generation drug-eluting coronary stents have reduced the risk of coronary events, especially in patients with complex disease or lesions.

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The swimming, swarming, twitching, and chemotaxis behaviors of mt2 were greater in the presence of glucose than that of Cd. People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. In 5 pts with non resectable neuroendocrine carcinoma of pancreas peptid radionuclide receptor therapy (PRRT) was indicated: in 4 of them with 90Ytrium-DOTA-octreotid and in 1 patient with MIBG.

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All patients underwent 2D echocardiography examination and (99m)Tc-MIBI myocardial perfusion imaging before coronary angiography was done. The ambitious and astronomically expensive project promises to bring economic opportunity to a poor country but it also carries risks to its tropical ecosystems.

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We present the case of a patient undergoing lumbar spine decompression for stenosis with a history of Mounier-Kuhn syndrome. We evaluated the anatomical course of the jugular vein, the diameter of the jugular foramen and the relation to the presence of papilledema.

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In this paper, we propose two new methods to effectively solve this problem by learning two discriminative affinity matrices from these weakly labeled images. Then, the initial P1 was divided into three positive activities (P1, P2, P3) in 9 subjects. HER2 immunohistochemistry (IHC) to 45 cases of bladder carcinoma, followed by fluorescent in situ hybridization (FISH) were applied. Specific meters investigated included a GE Biliblanket Light Meter II, a NeoBLUE radiometer and a Bio-TEK radiometer 74345 device.

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Triclosan causes toxic effects to algae in marine biofilms, but does not inhibit the metabolic activity of marine biofilm bacteria. Horizontal violence was inversely related to peer relations and quality of care, and positively related to errors and adverse events. IMT consists of inflammatory cells and myofibroblastic spindle cells. Several case-control studies have shown associations between the risk of different cancers and self-reported opium use. In the proposed method, a single in-line hologram is processed without phase shifting and multiplane reconstruction, so that a dynamic localization and tracking of particles becomes possible.

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Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse. In this isolated observation of the single factors, different antigen-structures occurred as result.

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Overview of human health and chemical mixtures: problems facing developing countries. A histological examination showed that the mass was SCLC at a clinical stage of cTisN0M0, stageIA, without local invasion. We investigated five call parameters that all showed a genomic dosage effect, i.e. He was started on itraconazole 200mg twice a day with rapid resolution of fever along with cessation of the development of new lesions. We present two cases in which we compared the efficacy of lite spot and lite brush in the treatment of psoriasis and vitiligo.

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Although ultrasound is often the first-line imaging modality in patients with adnexal masses, magnetic resonance imaging, computed tomography, and sometimes positron emission tomography-computed tomography are used for further evaluation. Crystallization behaviors of nanosized MgO particles from magnesium alkoxides.

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A field investigation into a suspected outbreak of pyrrolizidine alkaloid toxicosis in horses in western Queensland. Nonalcoholic Fatty Liver Disease Is Not Associated with Thyroid Hormone Levels and Hypothyroidism: A Systematic Review and Meta-Analysis.

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Experiences of ethical issues when caring for children with cancer. The prognosis and treatment of patients with multiple tumors may depend on the correlation between tumors: multiple primary tumors, or recurrent tumors, and metastatic disease. For black soil with high content of organic matter, organic cementing substance is an important factor in forming soil aggregates.

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Currently, a role for human endogenous retroviruses (HERVs) is also emerging in some autoimmune/immune-mediated diseases, particularly in multiple sclerosis (MS). To describe the pattern of surgical admissions to the Rift Valley Provincial General Hospital and in particular the epidemiologic characteristics of trauma admissions. Chimeric antigen receptors for treatment of glioblastoma: a practical review of challenges and ways to overcome them.

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From the results obtained it can be concluded that the modified method eliminated the potential danger associated with the use of hydrogen gas in the presence of flammable catalysts. The importance of age in patients for the subsequent state of the growth cartilage lengthened by distraction epiphysiolysis Inhibition of Kv current by 4-aminopyridine (0.5mM) and the Kv2 blocker stromatoxin (50nM) was additive and stromatoxin did not alter the potentiation of 4-aminopyridine effect by extracellular calcium. We performed this study as a comprehensive evaluation of variables reported to affect lower pole stone clearance after shock wave lithotripsy using artificial neural network analysis. The alteration in expression was supported by reverse transcription-polymerase chain reaction, western blotting, and immunohistochemical analysis of three selected proteins.

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The literature on the efficacy of epidural injections has been sporadic. Relationships between habitual physical activity and osteoarthrosis in ageing women. Personal hygiene practices were identified, such as hand washing, showers, tooth brushing and quitting smoking. Usefulness of brain SPECT imaging in the study of recurrent hypersomnia: Kleine-Levin syndrome. This article will review the infectious risks that occur as a result of natural disasters, with a focus on the mechanism of disease spread, infectious diseases after specific disasters, and various evidence-based interventions.

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Platelet retention in glass bead columns: its mechanism and the effect of plasma proteins. Antibody responses to Bordetella pertussis Fim2 or Fim3 following immunization with a whole-cell, two-component, or five-component acellular pertussis vaccine and following pertussis disease in children in Sweden in 1997 and 2007. We sought to investigate the risk factors for associated mortality in LT recipients with ESKAPE infections.

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Comparative efficacy and tolerability among different selective serotonin re-uptake inhibitors and venlafaxine in a naturalistic setting. Pregnancy status predicted general treatment preferences and pharmacotherapy, but not CBT, ratings. Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. Implications of these executive impairments in the development and maintenance of ED and obesity are discussed.

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To examine the use of ipratropium bromide in adults with acute exacerbation of either asthma or chronic obstructive pulmonary disease (COPD) during admission and at discharge from 3 teaching hospitals. Arterial oxygen saturation (SpO2) and heart rate (HR) were measured using pulse oximetry at the right hand/wrist. Identification and Functional Characterization of Small Alarmone Synthetases in Corynebacterium glutamicum.

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Using monocyte-derived osteoclast progenitors cultured within plasma clot/BCP microparticles composite, we aimed in the present report at the elucidation of transcriptional profiles of genes related to osteoclastogenesis and to bone remodelling. Brain tumors represent a vexing clinical problem in oncology due to their increasing incidence, difficulties in treatment and high rates of recurrence. In this study, auditory-evoked ERPs were generated in 13 older healthy volunteers using an oddball tone paradigm, after administration of single 0.5 and 2 mg doses of lorazepam. The medial wall of the resection was defined by the inferior-fronto-occipital fasciculus, protecting from the lenticulostriate arteries. For systematic reviews/meta-analysis the PRISMA-statement (formerly known as QUOROM) is recommended, as it gives the reader for a better understanding of the selection process.

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Recombinant protein FIZZ1 induces the expression of IL-8 and may thus participate in the process of chronic obstructive pulmonary disease airway inflammation and airflow obstruction. Risk prediction models for postoperative delirium: a systematic review and meta-analysis. Brachytherapy is an integrated part of the multidisciplinary treatment. Furthermore, there is an absence of evidence-based treatment strategies for addressing sexual problems. Against this background, the article aims to systematically map and assess for the first time ever the harms associated with cannabis cultivation, covering the whole spectrum of growers.

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Electron microscopy showed that the apical outgrowth possessed a thick, rough, highly fibrillar outer wall layer that was continuous with the thinner and smoother outer wall layer of the phialide. X-ray diffraction from a phase-shifting mask was used, and the coherence function was measured as a function of the width of beam-conditioning slits in the beam line.

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Acute cardiac events are a frequent cause of morbidity after vascular surgery. Safety of Live Robotic Surgery: Results from a Single Institution. A metabolic hypothesis is presented for insulin resistance in obesity, in the presence or absence of Type 2 (non-insulin-dependent) diabetes mellitus. We report evidence to show that under appropriate culture conditions, adult human SRC can also be induced to expand with limited differentiation. Reference lists of the identified articles were further used to identify other studies.

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To characterize the rate and risk factors for short-term readmission after spine fusion for deformity in pediatric patients. We also quantified intraglomerular PDGF-B mRNA by the competitive PCR and studied the correlation between the level of intraglomerular PDGF-B mRNA expression and the degree of observed glomerular injury. We present our experience of a pilot study that PDC was used in patients with poorgrade aSAH with associated intracerebral hematoma.

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These results confirmed that the greatest amounts of reactive material were produced by slow-growing organisms, although there were discrepancies between these results and those obtained by hemagglutination. Mortality rates and Cox regression models were used to analyze the association between urinary cannabis and mortality. Reduction by cimetidine of acute gastric hemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischemia in rats. Our structural analysis emphasizes the importance of accounting for structural plasticity of the ATP binding site in the design of type II inhibitors of tyrosine kinases. Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG.

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Complete Genome Sequence of Pluralibacter gergoviae FB2, an N-Acyl Homoserine Lactone-Degrading Strain Isolated from Packed Fish Paste. Splenectomy due to splenic abscess is without doubt an unusual occurrence, especially in Western countries. To improve teaching and create conditions as realistic as possible, a perfusion device was developed providing pulsatile flow through the vessels of different donor sites. According to this, cancer is sustained by highly positioned, chemoresistant cells with extensive capacity of self renewal, which are responsible for disease relapse after chemotherapy.

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Drugs that target these receptors or ligands can modulate the immune response by exerting antagonistic or agonistic effects. Near pulse overlap, the excitation pulses induce correlations that resemble signatures of dynamic inhomogeneity.

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Spatial, sequence-order-independent structural comparison of alpha/beta proteins: evolutionary implications. Metabolite assays showed that the probe was highly stable, making it suitable for in-vivo applications. As urologists are questioned about the overtreatment of localized prostate cancer, multiparametric MRI can diagnose significant prostate cancer thanks to targeted biopsies. These results suggest that our approach has the potential to uncover the molecular basis for ligand selectivity and off-target effects. Anterior hip dislocation in children with neurological disorders.

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Improving the effectiveness of the Trerotola Percutaneous Thrombectomy Device in thrombosed dialysis arteriovenous fistulas. rectus, and clearly indicates that one of the shared antigens is a GroEL protein possessing a biological activity that might play a role in the initiation and progression of periodontal disease. Seizure variables and their relationship to genotype and functional abilities in the CDKL5 disorder.

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Type 2 diabetic mellitus is associated with poorer prognosis among patients with NPC. Bone marrow aspiration studies confirmed haemophagocytic lymphohistiocytosis (HLH). Letter: Large Y chromosome found in polymorphs by a C-staining technique. Of the seven patients with acute leukemia de novo and del(20q), six were treated with only two achieving complete remission.

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A retrievable stent graft was inserted, and motor-evoked potentials were monitored to evaluate spinal cord ischemia. Specialist physicians require clinical information for patient visits in ambulatory encounters, some of which they may access via digital health solutions.

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Impact of osteopathic manipulative therapy in patient with deep with colorectal endometriosis: A classification based on symptoms and quality of life From shaping organelles to signalling platforms: the emerging functions of plant ER-PM contact sites. Coronary intramural hematomas can also occur iatrogenically, as a complication to percutaneous coronary intervention (PCI). Most concussions in community Australian football occurred through body contact with other players or during tackling.

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The column design parameters like adsorption rate constant, adsorption capacity and minimum bed depth were calculated. This paper will review these developments and attempt to identify remaining questions. Our analysis suggests that mpMRI followed by MRI-targeted biopsy is likely to result in fewer and better biopsies than TRUS-guided biopsy. Characterisation of molecular mechanisms that control tumour invasion is a crucial step for the identification of molecular markers to apply in cancer diagnosis and treatment. Colonic self-expandable metal stent placement is widely used for palliation of obstructive colorectal cancer.

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Framing life and death on YouTube: the strategic communication of organ donation messages by organ procurement organizations. Tumour-promoting hepatotoxins from the freshwater microcystin/nodularin class were identified in Northeastern Pacific Ocean, Eastern Canadian and European mussels for the first time. We identified shikonin as a candidate for shortening the circadian period using real-time reporter gene assays based on NIH3T3-derived stable reporter cells.

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The patients who have multiple mutations should be more in the front line considering their diagnosis, treatment and following up, and also in terms of decreasing mortality, morbidity and recurrence. The ethical dimension of treating the elderly, including risk-benefit analysis, focuses mainly on quality of life and end-of-life issues. In this study, different substances containing monounsaturated fatty acids were used to observe their protective effects in the HFD induced damage to liver and coronary vessels. We also aimed to determine patient characteristics associated with competent patient behavior. Mutation of the CRELD1 gene may increase the risk for AVSD rather crrt renal dosing clindamycin than being directly causative.

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Confluent NCI-H292 cells were pretreated with each agent for 30 min and then stimulated with EGF and PMA for 24h, respectively. The data indicate that ACH may play a role in the regulation of rat pineal gland secretion of AVT in vitro. When coordination framing emerged and came under arbitrary contextual control as an operant class, horseprerace omeprazole dosage a template was established for the development of multiple relational frames and the emergence and evolutionary impact of human cognition as we know it.

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The results indicate that patient prognosis remains poor regardless of the findings on (99m)Tc-labelled exametazime scintigraphy, but that the scan result influences the elapsed time to withdrawal of therapy or organ donation, providing a significant cost benefit, and augmentin tylenol drug interactions occasionally a long-term survivor is seen. Both of them are thought to regulate the enzymatic specificity and efficiency. We present a case of a 41-year-old female patient with progressive bilateral visual loss.

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In animals, artificial sperm and artificial oocytes generated from germline stem cells (GSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have resulted in the birth of viable offspring. A robust microfluidic device for the synthesis and crystal growth of organometallic polymers with highly organized structures. The posterior lens fibers exhibited cytoplasmic extensions into the posterior lens capsule, which was severely damaged in SPARC-null lenses. TP9201 may be an effective therapy for the prevention of re-thrombosis after thrombolytic therapy without adversely affecting hemostasis. Because DOTATOC has undergone extensive clinical testing, anadir vs agregarme this human reporter system has the potential for translation to human studies.

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The authors utilize a two-dimensional multilevel hybrid method to estimate local displacements and strain from the simulated cardiac oxybutynin chloride 10 mg tab radiofrequency data. The most common conditions include hemorrhage, vascular malformations and infarct. We believe that it is a very useful tool in the neurological examination of Cuban school children. Identification of related complications such as dissection, hematoma, ulceration, rupture, and thrombosis is also important. Further studies will be required to determine the functional effects of this polymorphism, its influence in disease pathogenesis, and its role in other ethnic groups.

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Molecular characteristics of rotavirus isolated from a diarrhea outbreak in october 2008 in bintuni bay, papua, indonesia. It is hoped that this review will provide guidance for further development of sacrificial bonding strategies in polymeric materials. This study shows these length variations result from inter-genomic insertion/deletion events (indels) involving horizontal transfer of ITS fragments ledifos medicine for diarrhea of other Acinetobacter species and possibly unrelated bacteria, as shown previously by us.

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As future therapies will require a deeper understanding of its cellular origins as well as the pathways that drive PCSC maintenance and tumorigenesis, we review the molecular and functional evidence supporting dysregulation of PI3K/AKT, RAS/MAPK and STAT3 signaling in PCSCs, the development of castration resistance, and as a novel treatment approach for individual men with prostate cancer. The results suggest that prepubertal trauma could be one etiologic factor for the development of mandibular asymmetry. Developmental changes in the expression and localization of drebrin has been mainly analyzed in chick embryo and young rat by various anti-drebrin polyclonal and monoclonal antibodies. Epicutaneous exposure to protein ivermectin injections for mange allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. D-dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation--observations from the ARISTOTLE trial.

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Balance control in lower extremity amputees during quiet standing: a systematic review. Additionally, FAK CKO mice displayed partial restoration of cell-cell junction lanzopral 30 mg roemmers laboratories proteins in the tumor vessels and astrocyte-endothelium interactions in tumors, revealing an additional role of astrocytes in mediating tumor-induced VP.

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Preliminary research data suggest that acupuncture may have an influence on metabolic parameters related to obesity. A bactoclav 625 tablet side effects pilot study assessing the association between paraoxonase 1 gene polymorphism and prostate cancer. In this chapter, we describe a workflow to perform a transcriptional and functional analysis of genome-wide target genes. It is suggested that supplementary immunoglobulin may be beneficial in amyloidosis.

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Eleven cases of systemic Pasteurella haemolytica infection in cattle were identified from routine diagnostic laboratory submissions during the falls of 1988, 1989, and 1991. At a molecular level, DPP-23 targeted the unfolded protein response (UPR) in the endoplasmic reticulum (ER) through the production of reactive oxygen species (ROS) in cancer cells, but not in normal cells, resulting in selective killing of tumor cells via caspase-dependent apoptosis. The activity was further improved via the flagyl breastfeeding kellymom medication combination of Ni2/3Fe1/3 LDH nanosheets with more conductive rGO (Ni2/3Fe1/3-rGO) to achieve an overpotential as low as 0.21 V and Tafel plot of 40 mV/decade. Structured examination routines have been developed as educational resources for musculoskeletal clinical skills teaching, including Gait-Arms-Legs-Spine (GALS), Regional Examination of the Musculoskeletal System (REMS) and paediatric GALS (pGALS).

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The present results indicated that PRL might involved in the pathogenesis of RA acyclovir iv infiltration treatment by regulating the secretion of MMP-9 in the synovium. Strains used for new probiotics should be chosen from the commensal flora of humans and should not carry intrinsic resistance to antibiotics that would prevent treatment of a rare probiotic infection.

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Chill-induced morphological alterations in Anacystis Nidulans as a function of growth temperature. Further investigation into how to minimize this embolic showering may help the cardiopulmonary at risk patient who requires spinal surgery, especially when multiple points of pedicle screw fixation are used. Indirect comparisons suggested that ESL, LAC and BRV were not supplin 500 mg metronidazole inferior to LEV in efficacy. Bone tissue types, vascular canal orientation and BGMs have been analyzed in 35 cross-sections of femur, tibia and metapodial bones of 9 individuals of different sexes, ages and habitats.